Tumor DNA Mutations From Intraparenchymal Brain Metastases Are Detectable in CSF

Discordant responses between brain metastases and extracranial tumors can arise from branched tumor evolution, underscoring the importance of profiling mutations to optimize therapy. However, the morbidity of brain biopsies limits their use. We investigated whether cell-free DNA (cfDNA) in CSF could...

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Bibliographic Details
Published in:JCO Precis Oncol
Main Authors: Cheok, Stephanie Kim, Narayan, Azeet, Arnal-Estape, Anna, Gettinger, Scott, Goldberg, Sarah B., Kluger, Harriet M., Nguyen, Don, Patel, Abhijit, Chiang, Veronica
Format: Artigo
Language:Inglês
Published: American Society of Clinical Oncology 2021
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Original Reports
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8232069/
https://ncbi.nlm.nih.gov/pubmed/34250381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.20.00292
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