Tumor DNA Mutations From Intraparenchymal Brain Metastases Are Detectable in CSF

Discordant responses between brain metastases and extracranial tumors can arise from branched tumor evolution, underscoring the importance of profiling mutations to optimize therapy. However, the morbidity of brain biopsies limits their use. We investigated whether cell-free DNA (cfDNA) in CSF could...

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Dettagli Bibliografici
Pubblicato in:JCO Precis Oncol
Autori principali: Cheok, Stephanie Kim, Narayan, Azeet, Arnal-Estape, Anna, Gettinger, Scott, Goldberg, Sarah B., Kluger, Harriet M., Nguyen, Don, Patel, Abhijit, Chiang, Veronica
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Clinical Oncology 2021
Soggetti:
Original Reports
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8232069/
https://ncbi.nlm.nih.gov/pubmed/34250381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.20.00292
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