Tumor DNA Mutations From Intraparenchymal Brain Metastases Are Detectable in CSF

Discordant responses between brain metastases and extracranial tumors can arise from branched tumor evolution, underscoring the importance of profiling mutations to optimize therapy. However, the morbidity of brain biopsies limits their use. We investigated whether cell-free DNA (cfDNA) in CSF could...

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Bibliografische gegevens
Gepubliceerd in:JCO Precis Oncol
Hoofdauteurs: Cheok, Stephanie Kim, Narayan, Azeet, Arnal-Estape, Anna, Gettinger, Scott, Goldberg, Sarah B., Kluger, Harriet M., Nguyen, Don, Patel, Abhijit, Chiang, Veronica
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Clinical Oncology 2021
Onderwerpen:
Original Reports
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8232069/
https://ncbi.nlm.nih.gov/pubmed/34250381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.20.00292
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