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Gap Junction-Mediated Intercellular Communication of cAMP Prevents CDDP-Induced Ototoxicity via cAMP/PKA/CREB Pathway

In the cochlea, non-sensory supporting cells are directly connected to adjacent supporting cells via gap junctions that allow the exchange of small molecules. We have previously shown that the pharmacological regulation of gap junctions alleviates cisplatin (CDDP)-induced ototoxicity in animal model...

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Detalles Bibliográficos
Publicado en:Int J Mol Sci
Autores principales: Kim, Yeon Ju, Lee, Jin-Sol, Kim, Hantai, Jang, Jeong Hun, Choung, Yun-Hoon
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI 2021
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC8231879/
https://ncbi.nlm.nih.gov/pubmed/34199197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms22126327
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