A Diels-Alder polymer platform for thermally enhanced drug release toward efficient local cancer chemotherapy

We reports a novel thermally enhanced drug release system synthesized via a dynamic Diels-Alder (DA) reaction to develop chemotherapy for pancreatic cancer. The anticancer prodrug was designed by tethering gemcitabine (GEM) to poly(furfuryl methacrylate) (PFMA) via N-(3-maleimidopropionyloxy)succini...

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Bibliographic Details
Published in:Sci Technol Adv Mater
Main Authors: Fujisawa, Nanami, Takanohashi, Masato, Chen, Lili, Uto, Koichiro, Matsumoto, Yoshitaka, Takeuchi, Masayuki, Ebara, Mitsuhiro
Format: Artigo
Language:Inglês
Published: Taylor & Francis 2021
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Focus on Trends in Biomaterials in Japan
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8231351/
https://ncbi.nlm.nih.gov/pubmed/34220340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14686996.2021.1939152
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