Large-Scale Imputation of KIR Copy Number and HLA Alleles in North American and European Psoriasis Case-Control Cohorts Reveals Association of Inhibitory KIR2DL2 With Psoriasis

Killer cell immunoglobulin-like receptors (KIR) regulate immune responses in NK and CD8+ T cells via interaction with HLA ligands. KIR genes, including KIR2DS1, KIR3DL1, and KIR3DS1 have previously been implicated in psoriasis susceptibility. However, these previous studies were constrained to small...

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Vydáno v:Front Immunol
Hlavní autoři: Ahn, Richard, Vukcevic, Damjan, Motyer, Allan, Nititham, Joanne, Squire, David McG., Hollenbach, Jill A., Norman, Paul J., Ellinghaus, Eva, Nair, Rajan P., Tsoi, Lam C., Oksenberg, Jorge, Foerster, John, Lieb, Wolfgang, Weidinger, Stephan, Franke, Andre, Elder, James T., Jorgenson, Eric, Leslie, Stephen, Liao, Wilson
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8231283/
https://ncbi.nlm.nih.gov/pubmed/34177931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.684326
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