Inhibition of the 3CL Protease and SARS-CoV-2 Replication by Dalcetrapib

[Image: see text] The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) 3CL protease is a promising target for inhibition of viral replication by interaction with a cysteine residue (Cys145) at its catalytic site. Dalcetrapib exerts its lipid-modulating effect by binding covalently to cys...

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Veröffentlicht in:ACS Omega
Hauptverfasser: Niesor, Eric J, Boivin, Guy, Rhéaume, Eric, Shi, Rong, Lavoie, Véronique, Goyette, Nathalie, Picard, Marie-Eve, Perez, Anne, Laghrissi-Thode, Fouzia, Tardif, Jean-Claude
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2021
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8230949/
https://ncbi.nlm.nih.gov/pubmed/34235330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsomega.1c01797
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