The C0-C1f Region of Cardiac Myosin Binding Protein-C Induces Pro-Inflammatory Responses in Fibroblasts via TLR4 Signaling

Myocardial injury is associated with inflammation and fibrosis. Cardiac myosin-binding protein-C (cMyBP-C) is cleaved by µ-calpain upon myocardial injury, releasing C0-C1f, an N-terminal peptide of cMyBP-C. Previously, we reported that the presence of C0-C1f is pathogenic within cardiac tissue and i...

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Gepubliceerd in:Cells
Hoofdauteurs: Yogeswaran, Athiththan, Troidl, Christian, McNamara, James W., Wilhelm, Jochen, Truschel, Theresa, Widmann, Laila, Aslam, Muhammad, Hamm, Christian W., Sadayappan, Sakthivel, Lipps, Christoph
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8230336/
https://ncbi.nlm.nih.gov/pubmed/34073556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cells10061326
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