Impact of TSPO Receptor Polymorphism on [(18)F]GE-180 Binding in Healthy Brain and Pseudo-Reference Regions of Neurooncological and Neurodegenerative Disorders

TSPO-PET tracers are sensitive to a single-nucleotide polymorphism (rs6971-SNP), resulting in low-, medium- and high-affinity binders (LABs, MABs and HABS), but the clinical relevance of [(18)F]GE-180 is still unclear. We evaluated the impact of rs6971-SNP on in vivo [(18)F]GE-180 binding in a healt...

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Publicat a:Life (Basel)
Autors principals: Vettermann, Franziska J., Harris, Stefanie, Schmitt, Julia, Unterrainer, Marcus, Lindner, Simon, Rauchmann, Boris-Stephan, Palleis, Carla, Weidinger, Endy, Beyer, Leonie, Eckenweber, Florian, Schuster, Sebastian, Biechele, Gloria, Ferschmann, Christian, Milenkovic, Vladimir M., Wetzel, Christian H., Rupprecht, Rainer, Janowitz, Daniel, Buerger, Katharina, Perneczky, Robert, Höglinger, Günter U., Levin, Johannes, Haass, Christian, Tonn, Joerg C., Niyazi, Maximilian, Bartenstein, Peter, Albert, Nathalie L., Brendel, Matthias
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8229996/
https://ncbi.nlm.nih.gov/pubmed/34073557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/life11060484
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