Activin-A Induces Early Differential Gene Expression Exclusively in Periodontal Ligament Fibroblasts from Fibrodysplasia Ossificans Progressiva Patients

Fibrodysplasia Ossificans Progressiva (FOP) is a rare genetic disease characterized by heterotopic ossification (HO). It is caused by mutations in the Activin receptor type 1 (ACVR1) gene, resulting in enhanced responsiveness to ligands, specifically to Activin-A. Though it has been shown that captu...

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Pubblicato in:Biomedicines
Autori principali: Schoenmaker, Ton, Mokry, Michal, Micha, Dimitra, Netelenbos, Coen, Bravenboer, Nathalie, Gilijamse, Marjolijn, Eekhoff, E. Marelise W., de Vries, Teun J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8229991/
https://ncbi.nlm.nih.gov/pubmed/34205844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biomedicines9060629
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