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Elaiophylin Is a Potent Hsp90/ Cdc37 Protein Interface Inhibitor with K-Ras Nanocluster Selectivity

The natural product elaiophylin is a macrodiolide with a broad range of biological activities. However, no direct target of elaiophylin in eukaryotes has been described so far, which hinders a systematic explanation of its astonishing activity range. We recently showed that the related conglobatin A...

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Bibliografische gegevens
Gepubliceerd in:Biomolecules
Hoofdauteurs: Siddiqui, Farid A., Vukic, Vladimir, Salminen, Tiina A., Abankwa, Daniel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2021
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8229862/
https://ncbi.nlm.nih.gov/pubmed/34199986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/biom11060836
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