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Improvement on Permeability of Cyclic Peptide/Peptidomimetic: Backbone N-Methylation as A Useful Tool

Peptides have a three-dimensional configuration that can adopt particular conformations for binding to proteins, which are well suited to interact with larger contact surface areas on target proteins. However, low cell permeability is a major challenge in the development of peptide-related drugs. In...

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Bibliografiske detaljer
Udgivet i:Mar Drugs
Main Authors: Li, Yang, Li, Wang, Xu, Zhengshuang
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2021
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8229464/
https://ncbi.nlm.nih.gov/pubmed/34072121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md19060311
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