Model-Informed Optimization of a Pediatric Clinical Pharmacokinetic Trial of a New Spironolactone Liquid Formulation

Quantitative pharmacology brings important advantages in the design and conduct of pediatric clinical trials. Herein, we demonstrate the application of a model-based approach to select doses and pharmacokinetic sampling scenarios for the clinical evaluation of a novel oral suspension of spironolacto...

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Publicado no:Pharmaceutics
Main Authors: Tatipalli, Manasa, Siripuram, Vijay Kumar, Long, Tao, Shuster, Diana, Bernstein, Galina, Martineau, Pierre, Cook, Kim A., Cristofoletti, Rodrigo, Schmidt, Stephan, Vozmediano, Valvanera
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8228864/
https://ncbi.nlm.nih.gov/pubmed/34201093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13060849
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