Quantitative Assessment of Levonorgestrel Binding Partner Interplay and Drug‐Drug Interactions Using Physiologically Based Pharmacokinetic Modeling

Levonorgestrel (LNG) is the active moiety in many hormonal contraceptive formulations. It is typically coformulated with ethinyl estradiol (EE) to decrease intermenstrual bleeding. Due to its widespread use and CYP3A4‐mediated metabolism, there is concern regarding drug‐drug interactions (DDIs), par...

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Bibliografiske detaljer
Udgivet i:CPT Pharmacometrics Syst Pharmacol
Main Authors: Cicali, Brian, Lingineni, Karthik, Cristofoletti, Rodrigo, Wendl, Thomas, Hoechel, Joachim, Wiesinger, Herbert, Chaturvedula, Ayyappa, Vozmediano, Valvanera, Schmidt, Stephan
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7825189/
https://ncbi.nlm.nih.gov/pubmed/33217171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12572
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