Quantitative Assessment of Levonorgestrel Binding Partner Interplay and Drug‐Drug Interactions Using Physiologically Based Pharmacokinetic Modeling

Levonorgestrel (LNG) is the active moiety in many hormonal contraceptive formulations. It is typically coformulated with ethinyl estradiol (EE) to decrease intermenstrual bleeding. Due to its widespread use and CYP3A4‐mediated metabolism, there is concern regarding drug‐drug interactions (DDIs), par...

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Enregistré dans:
Détails bibliographiques
Publié dans:CPT Pharmacometrics Syst Pharmacol
Auteurs principaux: Cicali, Brian, Lingineni, Karthik, Cristofoletti, Rodrigo, Wendl, Thomas, Hoechel, Joachim, Wiesinger, Herbert, Chaturvedula, Ayyappa, Vozmediano, Valvanera, Schmidt, Stephan
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7825189/
https://ncbi.nlm.nih.gov/pubmed/33217171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/psp4.12572
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