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Design, Synthesis, In Vitro and In Vivo Evaluation of Heterobivalent SiFAlin-Modified Peptidic Radioligands Targeting Both Integrin α(v)β(3) and the MC1 Receptor—Suitable for the Specific Visualization of Melanomas?

Combining two peptides addressing two different receptors to a heterobivalent peptidic ligand (HBPL) is thought to enable an improved tumor-targeting sensitivity and thus tumor visualization, compared to monovalent peptide ligands. In the case of melanoma, the Melanocortin-1 receptor (MC1R), which i...

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Detalles Bibliográficos
Publicado en:Pharmaceuticals (Basel)
Main Authors: Cheng, Xia, Hübner, Ralph, von Kiedrowski, Valeska, Fricker, Gert, Schirrmacher, Ralf, Wängler, Carmen, Wängler, Björn
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8228600/
https://ncbi.nlm.nih.gov/pubmed/34200477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14060547
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