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Next-Generation Sequencing of 487 Esophageal Adenocarcinomas Reveals Independently Prognostic Genomic Driver Alterations and Pathways

PURPOSE: To delineate recurrent oncogenic driver alterations and dysregulated pathways in esophageal adenocarcinoma and to assess their prognostic value. EXPERIMENTAL DESIGN: We analyzed a large cohort of patients with lower esophageal and junctional adenocarcinoma, prospectively sequenced by MSK-IM...

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Publicat a:Clin Cancer Res
Autors principals: Sihag, Smita, Nussenzweig, Samuel C., Walch, Henry S., Hsu, Meier, See Tan, Kay, Sanchez Vega, Francisco, Chatila, Walid K., De La Torre, Sergio, Patel, Assem, Janjigian, Yelena Y., Maron, Steven, Ku, Geoffrey Y., Tang, Laura H., Hechtman, Jaclyn, Shah, Pari M., Wu, Abraham, Jones, David R., Molena, Daniela, Solit, David B., Schultz, Nikolaus, Berger, Michael F.
Format: Artigo
Idioma:Inglês
Publicat: 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8228505/
https://ncbi.nlm.nih.gov/pubmed/33795256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-4707
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