Next-Generation Sequencing of 487 Esophageal Adenocarcinomas Reveals Independently Prognostic Genomic Driver Alterations and Pathways

PURPOSE: To delineate recurrent oncogenic driver alterations and dysregulated pathways in esophageal adenocarcinoma and to assess their prognostic value. EXPERIMENTAL DESIGN: We analyzed a large cohort of patients with lower esophageal and junctional adenocarcinoma, prospectively sequenced by MSK-IM...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Sihag, Smita, Nussenzweig, Samuel C., Walch, Henry S., Hsu, Meier, See Tan, Kay, Sanchez Vega, Francisco, Chatila, Walid K., De La Torre, Sergio, Patel, Assem, Janjigian, Yelena Y., Maron, Steven, Ku, Geoffrey Y., Tang, Laura H., Hechtman, Jaclyn, Shah, Pari M., Wu, Abraham, Jones, David R., Molena, Daniela, Solit, David B., Schultz, Nikolaus, Berger, Michael F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8228505/
https://ncbi.nlm.nih.gov/pubmed/33795256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-4707
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