Human Retrotransposons and the Global Shutdown of Homeostatic Innate Immunity by Oncolytic Parvovirus H-1PV in Pancreatic Cancer

Although the oncolytic parvovirus H-1PV has entered clinical trials, predicting therapeutic success remains challenging. We investigated whether the antiviral state in tumor cells determines the parvoviral oncolytic efficacy. The interferon/interferon-stimulated genes (IFN/ISG)-circuit and its major...

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Pubblicato in:Viruses
Autori principali: Neulinger-Muñoz, Matthias, Schaack, Dominik, Grekova, Svetlana P., Bauer, Andrea S., Giese, Thomas, Salg, Gabriel A., Espinet, Elisa, Leuchs, Barbara, Heller, Anette, Nüesch, Jürg P. F., Schenk, Miriam, Volkmar, Michael, Giese, Nathalia A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8228339/
https://ncbi.nlm.nih.gov/pubmed/34071585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/v13061019
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