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Novel Capsid-Specific Single-Domain Antibodies with Broad Foot-and-Mouth Disease Strain Recognition Reveal Differences in Antigenicity of Virions, Empty Capsids, and Virus-Like Particles

Foot-and-mouth disease (FMD) vaccine efficacy is mainly determined by the content of intact virions (146S) and empty capsids (75S). Both particles may dissociate into 12S subunits upon vaccine manufacturing, formulation, and storage, reducing vaccine potency. We report the isolation of capsid-specif...

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Podrobná bibliografie
Vydáno v:Vaccines (Basel)
Hlavní autoři: Li, Haozhou, Dekker, Aldo, Sun, Shiqi, Burman, Alison, Kortekaas, Jeroen, Harmsen, Michiel M.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8227720/
https://ncbi.nlm.nih.gov/pubmed/34201329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/vaccines9060620
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