Isolation of Single-Domain Antibody Fragments That Preferentially Detect Intact (146S) Particles of Foot-and-Mouth Disease Virus for Use in Vaccine Quality Control

Intact (146S) foot-and-mouth disease virus (FMDVs) can dissociate into specific (12S) viral capsid degradation products. FMD vaccines normally consist of inactivated virions. Vaccine quality is dependent on 146S virus particles rather than 12S particles. We earlier isolated two llama single-domain a...

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Detalles Bibliográficos
Publicado en:Front Immunol
Main Authors: Harmsen, Michiel M., Seago, Julian, Perez, Eva, Charleston, Bryan, Eblé, Phaedra L., Dekker, Aldo
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5562729/
https://ncbi.nlm.nih.gov/pubmed/28861080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.00960
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