Multiple Resistance Mechanisms to Tyrosine Kinase Inhibitors in EGFR Mutated Lung Adenocarcinoma: A Case Report Harboring EGFR Mutations, MET Amplification, and Squamous Cell Transformation

Resistance to EGFR tyrosin kinase inhibitors (TKI) inevitably occurs. Here it is reported the case of a young patient affected by lung adenocarcinoma harboring the L858R EGFR sensitive mutation. The patient developed multiple TKI resistance mechanisms: T790M EGFR resistance mutation, detected only o...

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Foilsithe in:Front Oncol
Main Authors: Bruno, Rossella, Del Re, Marzia, Cucchiara, Federico, Petrini, Iacopo, Alì, Greta, Crucitta, Stefania, Proietti, Agnese, Valleggi, Simona, Chella, Antonio, Danesi, Romano, Fontanini, Gabriella
Formáid: Artigo
Teanga:Inglês
Foilsithe: Frontiers Media S.A. 2021
Ábhair:
Oncology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8226241/
https://ncbi.nlm.nih.gov/pubmed/34178662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.674604
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