Interactive rather than independent effect of APOE and sex potentiates tau deposition in women

The apolipoprotein E gene (APOE) is the most important genetic risk factor for sporadic Alzheimer disease, with the ε4 allele being associated with increased cerebral amyloid-β and tau pathologies. Although APOE has been suggested to have a stronger effect in women as compared to men, there is a lac...

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Detalhes bibliográficos
Publicado no:Brain Commun
Main Authors: Wang, Yi-Ting T, Pascoal, Tharick A, Therriault, Joseph, Kang, Min Su, Benedet, Andréa L, Savard, Melissa, Tissot, Cécile, Lussier, Firoza Z, Arias, Jaime Fernandez, Mathotaarachchi, Sulantha, Rajah, Maria Natasha, Gauthier, Serge, Rosa-Neto, Pedro
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2021
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8226193/
https://ncbi.nlm.nih.gov/pubmed/34189460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/braincomms/fcab126
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