Prevalence and Spectrum of Germline BRCA1 and BRCA2 Variants of Uncertain Significance in Breast/Ovarian Cancer: Mysterious Signals From the Genome

About 10–20% of breast/ovarian (BC/OC) cancer patients undergoing germline BRCA1/2 genetic testing have been shown to harbor Variants of Uncertain Significance (VUSs). Since little is known about the prevalence of germline BRCA1/2 VUS in Southern Italy, our study aimed at describing the spectrum of...

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Vydáno v:Front Oncol
Hlavní autoři: Fanale, Daniele, Fiorino, Alessia, Incorvaia, Lorena, Dimino, Alessandra, Filorizzo, Clarissa, Bono, Marco, Cancelliere, Daniela, Calò, Valentina, Brando, Chiara, Corsini, Lidia Rita, Sciacchitano, Roberta, Magrin, Luigi, Pivetti, Alessia, Pedone, Erika, Madonia, Giorgio, Cucinella, Alessandra, Badalamenti, Giuseppe, Russo, Antonio, Bazan, Viviana
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2021
Témata:
Oncology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8226162/
https://ncbi.nlm.nih.gov/pubmed/34178674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.682445
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