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Nuclear ADP-ribosylation drives IFNγ-dependent STAT1α enhancer formation in macrophages

STAT1α is a key transcription factor driving pro-inflammatory responses in macrophages. We found that the interferon gamma (IFNγ)-regulated transcriptional program in macrophages is controlled by ADP-ribosylation (ADPRylation) of STAT1α, a post-translational modification resulting in the site-specif...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Gupte, Rebecca, Nandu, Tulip, Kraus, W. Lee
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8225886/
https://ncbi.nlm.nih.gov/pubmed/34168143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24225-2
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