Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy

The thrombospondin (Thbs) family of secreted matricellular proteins are stress- and injury-induced mediators of cellular attachment dynamics and extracellular matrix protein production. Here we show that Thbs1, but not Thbs2, Thbs3 or Thbs4, induces lethal cardiac atrophy when overexpressed. Mechani...

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Udgivet i:Nat Commun
Main Authors: Vanhoutte, Davy, Schips, Tobias G., Vo, Alexander, Grimes, Kelly M., Baldwin, Tanya A., Brody, Matthew J., Accornero, Federica, Sargent, Michelle A., Molkentin, Jeffery D.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8225674/
https://ncbi.nlm.nih.gov/pubmed/34168130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24215-4
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