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State-of-the-Art Native Mass Spectrometry and Ion Mobility Methods to Monitor Homogeneous Site-Specific Antibody-Drug Conjugates Synthesis

Antibody-drug conjugates (ADCs) are biotherapeutics consisting of a tumor-targeting monoclonal antibody (mAb) linked covalently to a cytotoxic drug. Early generation ADCs were predominantly obtained through non-selective conjugation methods based on lysine and cysteine residues, resulting in heterog...

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Bibliografske podrobnosti
izdano v:	Pharmaceuticals (Basel)
Main Authors:	Deslignière, Evolène, Ehkirch, Anthony, Duivelshof, Bastiaan L., Toftevall, Hanna, Sjögren, Jonathan, Guillarme, Davy, D’Atri, Valentina, Beck, Alain, Hernandez-Alba, Oscar, Cianférani, Sarah
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI 2021
Teme:	Article
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC8225019/ https://ncbi.nlm.nih.gov/pubmed/34073805 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14060498
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State-of-the-Art Native Mass Spectrometry and Ion Mobility Methods to Monitor Homogeneous Site-Specific Antibody-Drug Conjugates Synthesis

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