State-of-the-Art Native Mass Spectrometry and Ion Mobility Methods to Monitor Homogeneous Site-Specific Antibody-Drug Conjugates Synthesis

Antibody-drug conjugates (ADCs) are biotherapeutics consisting of a tumor-targeting monoclonal antibody (mAb) linked covalently to a cytotoxic drug. Early generation ADCs were predominantly obtained through non-selective conjugation methods based on lysine and cysteine residues, resulting in heterog...

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Vydáno v:Pharmaceuticals (Basel)
Hlavní autoři: Deslignière, Evolène, Ehkirch, Anthony, Duivelshof, Bastiaan L., Toftevall, Hanna, Sjögren, Jonathan, Guillarme, Davy, D’Atri, Valentina, Beck, Alain, Hernandez-Alba, Oscar, Cianférani, Sarah
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8225019/
https://ncbi.nlm.nih.gov/pubmed/34073805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ph14060498
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