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Insights from native mass spectrometry approaches for top- and middle- level characterization of site-specific antibody-drug conjugates
Antibody-drug conjugates (ADCs) have emerged as a family of compounds with promise as efficient immunotherapies. First-generation ADCs were generated mostly via reactions on either lysine side-chain amines or cysteine thiol groups after reduction of the interchain disulfide bonds, resulting in heter...
Shranjeno v:
| izdano v: | MAbs |
|---|---|
| Main Authors: | , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Taylor & Francis
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5524152/ https://ncbi.nlm.nih.gov/pubmed/28406343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1316914 |
| Oznake: |
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