Insights from native mass spectrometry approaches for top- and middle- level characterization of site-specific antibody-drug conjugates

Antibody-drug conjugates (ADCs) have emerged as a family of compounds with promise as efficient immunotherapies. First-generation ADCs were generated mostly via reactions on either lysine side-chain amines or cysteine thiol groups after reduction of the interchain disulfide bonds, resulting in heter...

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Veröffentlicht in:MAbs
Hauptverfasser: Botzanowski, Thomas, Erb, Stéphane, Hernandez-Alba, Oscar, Ehkirch, Anthony, Colas, Olivier, Wagner-Rousset, Elsa, Rabuka, David, Beck, Alain, Drake, Penelope M., Cianférani, Sarah
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5524152/
https://ncbi.nlm.nih.gov/pubmed/28406343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1316914
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