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Towards a streamlined synthesis of peptides containing α,β-dehydroamino acids

Investigation of a strategy to streamline the synthesis of peptides containing α,β-dehydroamino acids (ΔAAs) is reported. The key step involves generating the alkene moiety via elimination of a suitable precursor after it has been inserted into a peptide chain. This process obviates the need to prep...

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Detalhes bibliográficos
Publicado no:Tetrahedron Lett
Main Authors: Moyá, Diego A., Lee, Michael A., Chanthakhoun, Joseph C., LeSueur, Austin K., Joaquin, Daniel, Barfuss, Jaden D., Castle, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8224935/
https://ncbi.nlm.nih.gov/pubmed/34176981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2021.153175
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