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Bulky Dehydroamino Acids Enhance Proteolytic Stability and Folding in β-Hairpin Peptides
The bulky dehydroamino acids dehydrovaline (ΔVal) and dehydroethylnorvaline (ΔEnv) can be inserted into the turn regions of β-hairpin peptides without altering their secondary structures. These residues increase proteolytic stability, with ΔVal at the (i + 1) position having the most substantial imp...
Gardado en:
| Publicado en: | Org Lett |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6085080/ https://ncbi.nlm.nih.gov/pubmed/28910115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.7b02455 |
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