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De Novo Synthesis of an l-Lemonose Thioglycoside Donor from d-Threonine

A short de novo synthesis of an l-lemonose thioglycoside is described starting from d-threonine. The synthesis leverages a Dieckmann condensation and Stork-Danheiser transposition to arrive at a key vinylogous ester intermediate on gram scale. Ensuing 1,2-addition diastereoselectively establishes th...

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Publicat a:Tetrahedron Lett
Autors principals: Huseman, Eric D., Townsend, Steven D.
Format: Artigo
Idioma:Inglês
Publicat: 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8224840/
https://ncbi.nlm.nih.gov/pubmed/34176980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2021.153097
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