Patient-derived cell lines and orthotopic mouse model of peritoneal carcinomatosis recapitulate molecular and phenotypic features of human gastric adenocarcinoma

BACKGROUND: Gastric adenocarcinoma with peritoneal carcinomatosis (PC) is therapy resistant and leads to poor survival. To study PC in depth, there is an urgent need to develop representative PC-derived cell lines and metastatic models to study molecular mechanisms of PC and for preclinical screenin...

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Publicat a:J Exp Clin Cancer Res
Autors principals: Song, Shumei, Xu, Yan, Huo, Longfei, Zhao, Shuangtao, Wang, Ruiping, Li, Yuan, Scott, Ailing W., Pizzi, Melissa Pool, Wang, Ying, Fan, Yibo, Harada, Kazuto, Jin, Jiankang, Ma, Lang, Yao, Xiaodan, Shanbhag, Namita D., Gan, Qiong, Roy-Chowdhuri, Sinchita, Badgwell, Brian D., Wang, Zhenning, Wang, Linghua, Ajani, Jaffer A.
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2021
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8223395/
https://ncbi.nlm.nih.gov/pubmed/34162421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-021-02003-8
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