Phthalide derivative CD21 attenuates tissue plasminogen activator-induced hemorrhagic transformation in ischemic stroke by enhancing macrophage scavenger receptor 1-mediated DAMP (peroxiredoxin 1) clearance

BACKGROUND: Hemorrhagic transformation (HT) is a critical issue in thrombolytic therapy in acute ischemic stroke. Damage-associated molecular pattern (DAMP)-stimulated sterile neuroinflammation plays a crucial role in the development of thrombolysis-associated HT. Our previous study showed that the...

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Udgivet i:J Neuroinflammation
Main Authors: Liu, Dong-Ling, Hong, Zhi, Li, Jing-Ying, Yang, Yu-Xin, Chen, Chu, Du, Jun-Rong
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2021
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8223381/
https://ncbi.nlm.nih.gov/pubmed/34162400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-021-02170-7
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