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Environmental enrichment preserves a young DNA methylation landscape in the aged mouse hippocampus

The decline of brain function during aging is associated with epigenetic changes, including DNA methylation. Lifestyle interventions can improve brain function during aging, but their influence on age-related epigenetic changes is unknown. Using genome-wide DNA methylation sequencing, we here show t...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Zocher, Sara, Overall, Rupert W., Lesche, Mathias, Dahl, Andreas, Kempermann, Gerd
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2021
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8222384/
https://ncbi.nlm.nih.gov/pubmed/34162876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23993-1
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