Reduced dose of PTCy followed by adjuvant α-galactosylceramide enhances GVL effect without sacrificing GVHD suppression

Posttransplantation cyclophosphamide (PTCy) has become a popular option for haploidentical hematopoietic stem cell transplantation (HSCT). However, personalized methods to adjust immune intensity after PTCy for each patient’s condition have not been well studied. Here, we investigated the effects of...

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Vydáno v:Sci Rep
Hlavní autoři: Nakamura, Makoto, Meguri, Yusuke, Ikegawa, Shuntaro, Kondo, Takumi, Sumii, Yuichi, Fukumi, Takuya, Iwamoto, Miki, Sando, Yasuhisa, Sugiura, Hiroyuki, Asada, Noboru, Ennishi, Daisuke, Tomida, Shuta, Fukuda-Kawaguchi, Emi, Ishii, Yasuyuki, Maeda, Yoshinobu, Matsuoka, Ken-ichi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8222309/
https://ncbi.nlm.nih.gov/pubmed/34162921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-92526-z
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