CGRP, adrenomedullin and adrenomedullin 2 display endogenous GPCR agonist bias in primary human cardiovascular cells

Agonist bias occurs when different ligands produce distinct signalling outputs when acting at the same receptor. However, its physiological relevance is not always clear. Using primary human cells and gene editing techniques, we demonstrate endogenous agonist bias with physiological consequences for...

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Detalhes bibliográficos
Publicado no:Commun Biol
Main Authors: Clark, Ashley J., Mullooly, Niamh, Safitri, Dewi, Harris, Matthew, de Vries, Tessa, MaassenVanDenBrink, Antoinette, Poyner, David R., Gianni, Davide, Wigglesworth, Mark, Ladds, Graham
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8222276/
https://ncbi.nlm.nih.gov/pubmed/34163006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-021-02293-w
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