Immunodominant T-cell epitopes from the SARS-CoV-2 spike antigen reveal robust pre-existing T-cell immunity in unexposed individuals

The COVID-19 pandemic has revealed a range of disease phenotypes in infected patients with asymptomatic, mild, or severe clinical outcomes, but the mechanisms that determine such variable outcomes remain unresolved. In this study, we identified immunodominant CD8 T-cell epitopes in the spike antigen...

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Udgivet i:Sci Rep
Main Authors: Mahajan, Swapnil, Kode, Vasumathi, Bhojak, Keshav, Karunakaran, Coral, Lee, Kayla, Manoharan, Malini, Ramesh, Athulya, HV, Sudheendra, Srivastava, Ankita, Sathian, Rekha, Khan, Tahira, Kumar, Prasanna, Gupta, Ravi, Chakraborty, Papia, Chaudhuri, Amitabha
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8222233/
https://ncbi.nlm.nih.gov/pubmed/34162945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-92521-4
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