Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease

ARH3/ADPRHL2 and PARG are the primary enzymes reversing ADP-ribosylation in vertebrates, yet their functions in vivo remain unclear. ARH3 is the only hydrolase able to remove serine-linked mono(ADP-ribose) (MAR) but is much less efficient than PARG against poly(ADP-ribose) (PAR) chains in vitro. Her...

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Publicado no:Mol Cell
Main Authors: Prokhorova, Evgeniia, Agnew, Thomas, Wondisford, Anne R., Tellier, Michael, Kaminski, Nicole, Beijer, Danique, Holder, James, Groslambert, Josephine, Suskiewicz, Marcin J., Zhu, Kang, Reber, Julia M., Krassnig, Sarah C., Palazzo, Luca, Murphy, Shona, Nielsen, Michael L., Mangerich, Aswin, Ahel, Dragana, Baets, Jonathan, O’Sullivan, Roderick J., Ahel, Ivan
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221567/
https://ncbi.nlm.nih.gov/pubmed/34019811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2021.04.028
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