CaMKII Serine 280 O-GlcNAcylation Links Diabetic Hyperglycemia to Proarrhythmia

RATIONALE: Diabetic hyperglycemia is associated with cardiac dysfunction and increased arrhythmia risk, and CaMKII (calcium/calmodulin-dependent protein kinase II) function has been implicated. CaMKII activity is promoted by both oxidation and O-linked β-N-acetylglucosamine (O-GlcNAc) of known CaMKI...

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Detalhes bibliográficos
Publicado no:Circ Res
Main Authors: Hegyi, Bence, Fasoli, Anna, Ko, Christopher Y., Van, Benjamin W., Alim, Chidera C., Shen, Erin Y., Ciccozzi, Marisa M., Tapa, Srinivas, Ripplinger, Crystal M., Erickson, Jeffrey R., Bossuyt, Julie, Bers, Donald M.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2021
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221539/
https://ncbi.nlm.nih.gov/pubmed/33926209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.120.318402
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