CHD4 regulates platinum sensitivity through MDR1 expression in ovarian cancer: A potential role of CHD4 inhibition as a combination therapy with platinum agents

Platinum sensitivity is an important prognostic factor in patients with ovarian cancer. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a core member of the nucleosome remodeling and deacetylase complex, which functions as a chromatin remodeler. Emerging evidence indicates that CHD4 could be a...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Oyama, Yoshiko, Shigeta, Shogo, Tokunaga, Hideki, Tsuji, Keita, Ishibashi, Masumi, Shibuya, Yusuke, Shimada, Muneaki, Yasuda, Jun, Yaegashi, Nobuo
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8221472/
https://ncbi.nlm.nih.gov/pubmed/34161330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0251079
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