New homozygous gpt delta transgenic rat strain improves an efficiency of the in vivo mutagenicity assay

BACKGROUND: Gene mutation assays in transgenic rodents are useful tools to investigate in vivo mutagenicity in a target tissue. Using a lambda EG10 transgene containing reporter genes, gpt delta transgenic mice and rats have been developed to detect point mutations and deletions. The transgene is in...

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Detalhes bibliográficos
Publicado no:Genes Environ
Main Authors: Masumura, Kenichi, Ando, Tomoko, Ukai, Akiko, Fujiwara, Sho, Yokose, Shigeo, You, Xinyue, Suzuki, Takayoshi, Hayashi, Hiroyuki, Nohmi, Takehiko, Takagi, Hisayoshi, Honma, Masamitsu
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2021
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8220708/
https://ncbi.nlm.nih.gov/pubmed/34158118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s41021-021-00195-1
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