A fragment-based approach to assess the ligandability of ArgB, ArgC, ArgD and ArgF in the L-arginine biosynthetic pathway of Mycobacterium tuberculosis

The L-arginine biosynthesis pathway consists of eight enzymes that catalyse the conversion of L-glutamate to L-arginine. Arginine auxotrophs (argB/argF deletion mutants) of Mycobacterium tuberculosis are rapidly sterilised in mice, while inhibition of ArgJ with Pranlukast was found to clear chronic...

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Detalhes bibliográficos
Publicado no:Comput Struct Biotechnol J
Main Authors: Gupta, Pooja, Thomas, Sherine E., Zaidan, Shaymaa A., Pasillas, Maria A., Cory-Wright, James, Sebastián-Pérez, Víctor, Burgess, Ailidh, Cattermole, Emma, Meghir, Clio, Abell, Chris, Coyne, Anthony G., Jacobs, William R., Blundell, Tom L., Tiwari, Sangeeta, Mendes, Vítor
Formato: Artigo
Idioma:Inglês
Publicado em: Research Network of Computational and Structural Biotechnology 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8220418/
https://ncbi.nlm.nih.gov/pubmed/34194673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.csbj.2021.06.006
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