Transfer of a human gene variant associated with exceptional longevity improves cardiac function in obese type 2 diabetic mice through induction of the SDF‐1/CXCR4 signalling pathway

AIMS: Homozygosity for a four‐missense single‐nucleotide polymorphism haplotype of the human BPIFB4 gene is enriched in long‐living individuals. Delivery of this longevity‐associated variant (LAV) improved revascularisation and reduced endothelial dysfunction and atherosclerosis in mice through a me...

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Bibliografiske detaljer
Udgivet i:Eur J Heart Fail
Main Authors: Dang, Zexu, Avolio, Elisa, Thomas, Anita C., Faulkner, Ashton, Beltrami, Antonio P., Cervellin, Celeste, Carrizzo, Albino, Maciag, Anna, Gu, Yue, Ciaglia, Elena, Finato, Nicoletta, Damato, Antonio, Spinetti, Gaia, Alenzi, Aishah, Paisey, Stephen J., Vecchione, Carmine, Puca, Annibale A., Madeddu, Paolo
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Ltd. 2020
Fag:
Pathophysiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8220375/
https://ncbi.nlm.nih.gov/pubmed/32384208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ejhf.1840
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