The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation

Atr is a serine/threonine kinase, known to sense single-stranded DNA breaks and activate the DNA damage checkpoint by phosphorylating Chek1, which inhibits Cdc25, causing cell cycle arrest. This pathway has not been implicated in neuroregeneration. We show that in Drosophila sensory neurons removing...

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Udgivet i:Nat Commun
Main Authors: Li, Feng, Lo, Tsz Y., Miles, Leann, Wang, Qin, Noristani, Harun N., Li, Dan, Niu, Jingwen, Trombley, Shannon, Goldshteyn, Jessica I., Wang, Chuxi, Wang, Shuchao, Qiu, Jingyun, Pogoda, Katarzyna, Mandal, Kalpana, Brewster, Megan, Rompolas, Panteleimon, He, Ye, Janmey, Paul A., Thomas, Gareth M., Li, Shuxin, Song, Yuanquan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8219705/
https://ncbi.nlm.nih.gov/pubmed/34158506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24131-7
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