LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling

The molecular mechanism underlying pancreatic ductal adenocarcinoma (PDAC) malignancy remains unclear. Here, we characterize a long intergenic non-coding RNA LINC00842 that plays a role in PDAC progression. LINC00842 expression is upregulated in PDAC and induced by high concentration of glucose via...

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Vydáno v:Nat Commun
Hlavní autoři: Huang, Xudong, Pan, Ling, Zuo, Zhixiang, Li, Mei, Zeng, Lingxing, Li, Rui, Ye, Ying, Zhang, Jialiang, Wu, Guandi, Bai, Ruihong, Zhuang, Lisha, Wei, Lusheng, Zheng, Yanfen, Su, Jiachun, Deng, Junge, Deng, Shuang, Zhang, Shaoping, Zhu, Shihao, Che, Xu, Wang, Chengfeng, Wu, Chen, Chen, Rufu, Lin, Dongxin, Zheng, Jian
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2021
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8219694/
https://ncbi.nlm.nih.gov/pubmed/34158490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23904-4
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