Impaired Autophagy Induced by oxLDL/β2GPI/anti-β2GPI Complex through PI3K/AKT/mTOR and eNOS Signaling Pathways Contributes to Endothelial Cell Dysfunction

Endothelial cell dysfunction plays a fundamental role in the pathogenesis of atherosclerosis (AS), and endothelial autophagy has protective effects on the development of AS. Our previous study had shown that oxidized low-density lipoprotein/β2-glycoprotein I/anti-β2-glycoprotein I antibody (oxLDL/β2...

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Vydáno v:Oxid Med Cell Longev
Hlavní autoři: Zhang, Guiting, He, Chao, Wu, Qianqian, Xu, Guoying, Kuang, Ming, Wang, Ting, Xu, Liangjie, Zhou, Hong, Yuan, Wei
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2021
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8219424/
https://ncbi.nlm.nih.gov/pubmed/34221236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2021/6662225
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