Reduced PHLPP Expression Leads to EGFR-TKI Resistance in Lung Cancer by Activating PI3K-AKT and MAPK-ERK Dual Signaling

BACKGROUND: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are effective in advanced EGFR-mutation non-small cell lung cancer (NSCLC) but the magnitude of tumor regression varies, and drug resistance is unavoidable. The pleckstrin homology domain leucine-rich repeat protein...

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Dettagli Bibliografici
Pubblicato in:Front Oncol
Autori principali: Wang, Wei, Xia, Xinhang, Chen, Kuifei, Chen, Meng, Meng, Yinnan, Lv, Dongqing, Yang, Haihua
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021
Soggetti:
Oncology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217757/
https://ncbi.nlm.nih.gov/pubmed/34168988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2021.665045
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