ERRγ enhances cardiac maturation with T-tubule formation in human iPSC-derived cardiomyocytes

One of the earliest maturation steps in cardiomyocytes (CMs) is the sarcomere protein isoform switch between TNNI1 and TNNI3 (fetal and neonatal/adult troponin I). Here, we generate human induced pluripotent stem cells (hiPSCs) carrying a TNNI1(EmGFP) and TNNI3(mCherry) double reporter to monitor an...

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Udgivet i:Nat Commun
Main Authors: Miki, Kenji, Deguchi, Kohei, Nakanishi-Koakutsu, Misato, Lucena-Cacace, Antonio, Kondo, Shigeru, Fujiwara, Yuya, Hatani, Takeshi, Sasaki, Masako, Naka, Yuki, Okubo, Chikako, Narita, Megumi, Takei, Ikue, Napier, Stephanie C., Sugo, Tsukasa, Imaichi, Sachiko, Monjo, Taku, Ando, Tatsuya, Tamura, Norihisa, Imahashi, Kenichi, Nishimoto, Tomoyuki, Yoshida, Yoshinori
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217550/
https://ncbi.nlm.nih.gov/pubmed/34155205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23816-3
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