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Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly
Centrioles are evolutionarily conserved multi-protein organelles essential for forming cilia and centrosomes. Centriole biogenesis begins with self-assembly of SAS-6 proteins into 9-fold symmetrical ring polymers, which then stack into a cartwheel that scaffolds organelle formation. The importance o...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group UK
2021
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8217511/ https://ncbi.nlm.nih.gov/pubmed/34155202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-23897-0 |
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