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Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide

To be effective, chemotherapy against tuberculosis (TB) must kill the intracellular population of the pathogen, Mycobacterium tuberculosis. However, how host cell microenvironments affect antibiotic accumulation and efficacy remains unclear. Here, we use correlative light, electron, and ion microsco...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Santucci, Pierre, Greenwood, Daniel J., Fearns, Antony, Chen, Kai, Jiang, Haibo, Gutierrez, Maximiliano G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217510/
https://ncbi.nlm.nih.gov/pubmed/34155215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24127-3
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