Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH

BACKGROUND & AIMS: Perturbations of intracellular magnesium (Mg(2+)) homeostasis have implications for cell physiology. The cyclin M family, CNNM, perform key functions in the transport of Mg(2+) across cell membranes. Herein, we aimed to elucidate the role of CNNM4 in the development of non-alc...

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Publié dans:J Hepatol
Auteurs principaux: Simón, Jorge, Goikoetxea-Usandizaga, Naroa, Serrano-Maciá, Marina, Fernández-Ramos, David, Sáenz de Urturi, Diego, Gruskos, Jessica J., Fernández-Tussy, Pablo, Lachiondo-Ortega, Sofía, González-Recio, Irene, Rodríguez-Agudo, Rubén, Gutiérrez-de-Juan, Virginia, Rodríguez-Iruretagoyena, Begoña, Varela-Rey, Marta, Gimenez-Mascarell, Paula, Mercado-Gomez, María, Gómez-Santos, Beatriz, Fernandez-Rodriguez, Carmen, Lopitz-Otsoa, Fernando, Bizkarguenaga, Maider, Dames, Sibylle, Schaeper, Ute, Martin, Franz, Sabio, Guadalupe, Iruzubieta, Paula, Crespo, Javier, Aspichueta, Patricia, Chu, Kevan H.-Y., Buccella, Daniela, Martín, César, Delgado, Teresa Cardoso, Martínez-Cruz, Luis Alfonso, Martínez-Chantar, María Luz
Format: Artigo
Langue:Inglês
Publié: 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8217299/
https://ncbi.nlm.nih.gov/pubmed/33571553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2021.01.043
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