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Optimizing mitochondrial maintenance in extended neuronal projections

Neurons rely on localized mitochondria to fulfill spatially heterogeneous metabolic demands. Mitochondrial aging occurs on timescales shorter than the neuronal lifespan, necessitating transport of fresh material from the soma. Maintaining an optimal distribution of healthy mitochondria requires an i...

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Publicat a:PLoS Comput Biol
Autors principals: Agrawal, Anamika, Koslover, Elena F.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8216566/
https://ncbi.nlm.nih.gov/pubmed/34106921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1009073
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